Study Shows Ozempic Is Linked to Lower Risk of Worsening Mental Health Issues

Semaglutide, the main ingredient in both drugs, was linked to a 44% lower risk of worsening depression.

Photographer: Eric Thayer/Bloomberg

Swedish people with depression and anxiety who took Novo Nordisk A/S’s blockbuster shots Ozempic and Wegovy were less likely to see their mental health get worse, the latest data to suggest that popular diabetes and obesity drugs could also have a broader impact on well-being.

Semaglutide, the main ingredient in both drugs, was linked to a 44% lower risk of worsening depression, a 38% lower risk of worsening anxiety and a 47% lower risk of worsening addiction, in results published in The Lancet Psychiatry journal. The researchers followed almost 95,000 people who had diabetes or obesity and a mental health diagnosis.